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In contrast, low-dose testosterone or nandrolone use results in substantial suppression of natural testosterone, and so there is less total effectdue to the low androgen content in the testes. With this in mind, it is the only plausible explanation for the observed increase in endogenous testosterone and its long-term consequence in the testes.This finding strongly raises the concern about the use of nandrolone alone compared to other steroids. The use of nandrolone alone is not expected to change sexual function despite being more effective in inhibiting the production of endogenous testosterone in men. Other hormones with lower affinity for steroid receptors, such as cortisol and growth factors, may be equally capable of inhibiting androgen production, however, such hormones may not be required after nandrolone use. Furthermore, this finding appears to be not independent of baseline testosterone levels in the men.There will be no major reduction of the production of endogenous testosterone, and the effects of testosterone on spermatogenesis remain strong. However, there could be a major reduction in the testosterone production by the testes (due to an incomplete or inadequate reduction of spermatogenesis), a possible side effect of nandrolone itself, as it has been proven that testosterone can decrease spermatogenesis (Panksepp & van Meirnden, 1992; van Meirnden & Korteweg, 2006). This could explain the findings that men with low endogenous testosterone levels had decreased spermatogenesis after nandrolone in the pre-menopausal group. Low endogenous testosterone levels are also likely to contribute to reduced sexual function in young men, which has also been confirmed by studies investigating the effects of testosterone replacement therapy in young men (Panksepp et al., 1993), and in postmenopausal women (Rösner, 1996). The use of high-dose testosterone or estrogen is also likely to be detrimental for sexual functioning. Low-dose testosterone or estrogen is not a good choice for pre-menopausal women after menopause, because they can develop high risk of prostate cancer which requires treatment with the anti-proliferative compound, tamoxifen (Rösner, 1996), with subsequent loss of sexual function, as they age (Liu-Hsiung et al., 2006a).In summary, it seems evident that the use of nandrolone alone is only one component of the male reproductive system and will not in itself influence sexual function. The testes may also be a source of male hormones that affect sexual function.Cognitive enhancementThe effect of low or increasedSimilar articles: